This paper presents the manner in which the DNA, the molecule of life, was discovered. Unlike what many people, even biologists, believe, it was Johannes Friedrich Miescher who originally discovered and isolated nuclein, currently known as DNA, in 1869, 75 years before Watson and Crick unveiled its structure. Also, in this paper we show, and above all demonstrate, the serendipity of this major discovery. Like many of his contemporaries, Miescher set out to discover how cells worked by means of studying (...) and analysing their proteins. During this arduous task, he detected an unexpected substance of unpredicted properties. This new substance precipitated when he added acid to the solution and it dissolved again when adding alkali. Unexpectedly and by a mere fluke, Miescher was the first person to obtain a DNA precipitate. The paper then presents the term serendipity and discusses how it has influenced the discovery of other important scientific milestones. Finally, we address the question of whether serendipitous discoveries can be nurtured and what role the computer could play in this process. (shrink)

In the centenary year of Turing’s birth, a lot of good things are sure to be written about him. But it is hard to find something new to write about Turing. This is the biggest merit of this article: it shows how von Neumann’s architecture of the modern computer is a serendipitous consequence of the universal Turing machine, built to solve a logical problem.

In recent decades, there has been a proliferation among the scientific community of works that focus on Alan Turing’s contributions to the design and development of the modern computer. However, there are significant discrepancies among these studies, to such a point that some of them cast serious doubts on Alan Turing’s work with respect to today’s computer, and there are others that staunchly defend his leading role, as well as other studies that set out more well-balanced opinions. Faced with this (...) situation, the aim of this paper is to analyse the evidence existing today in order to be able to draw a conclusion about whether or not Turing anticipated the trivialisation of the modern computer memory and, likewise, if his universal a-machine is the precursor of the general-purpose computer so omnipresent today. As a result of our research, the authors conclude that Turing did indeed play a leading role in the appearance of the modern computer, although he was not the only one or the first in the field of Computing Science, albeit he was the most influential, both in scope and in depth. (shrink)

Turing was an exceptional mathematician with a peculiar and fascinating personality and yet he remains largely unknown. In fact, he might be considered the father of the von Neumann architecture computer and the pioneer of Artificial Intelligence. And all thanks to his machines; both those that Church called “Turing machines” and the a-, c-, o-, unorganized- and p-machines, which gave rise to evolutionary computations and genetic programming as well as connectionism and learning. This paper looks at all of these and (...) at why he is such an often overlooked and misunderstood figure. (shrink)

Previous research has shown that student plagiarism is the product of interplay between individual and situational factors. The present study examined the relationship between these two sets of factors with a particular focus on variables linked to students’ academic context namely, their perception of peer behaviors, their experience of adversities in academic life, and their year of enrollment. So far, these situational features have received scant attention in studies of plagiarism conducted in most of Europe. A survey was carried out (...) in a European higher education institution, involving a sample of 427 undergraduates. The data was analyzed via both conventional univariate and bivariate statistical analysis, and multivariate, multilevel modeling. The results suggest that awareness of peer plagiarizing and the experience of hardships in academic life, rather than level of academic achievement or year of study, are significantly related to plagiarizing, whereas heightened perception of the seriousness of plagiarism is associated with a lower likelihood of this type of behavior. The study also shows that students who plagiarize are more likely to be involved in other types of academic misconduct. (shrink)

Agustín Rivera publicó en 1887 Filosofía en la Nueva España, obra muy crítica de la filosofía y la ciencia novohispanas. Agustín de la Rosa contestó defensivamente con La instrucción en México durante su dependencia de España (1888). El presente libro ofrece amplio detalle de esa polémica, hasta en los aspectos de técnica de la discusión, y es sin duda de utilidad. Sobre el tema recordamos también Dos ideas sobre la filosofía en la Nueva España (1959) de Juan Hernández Luna, reseñada (...) en HLAS 22:5836, y extrañamente omitida en la bibliografía de la obra que comentamos"--Handbook of Latin American Studies, v. 58. (shrink)

A novidade do Deus cristão apresentado por Jesus Cristo é a Trindade. Sem contradizer o monoteísmo judeu, a reflexão para formulação dogmática se estendeu por quatro séculos. Sucessivamente, a Trindade foi tema esquecido na Igreja por 1.600 anos. Sua importância está sendo redescoberta não somente na liturgia, mas, também, na vida e na reflexão eclesial. A unidade no amor dos Três distintos, Pai, Filho e Espírito Santo, estimula a espiritualidade e a vivência do cristão de hoje. Para tanto, é necessário (...) o auxílio das ciências humanas, que permitem a atualização da linguagem do dogma sem a perda do seu conteúdo fundamental. A reflexão do teólogo napolitano Bruno Forte dá uma grande contribuição para a teologia atual, respeitando a formulação dogmática e, ao mesmo tempo, buscando categorias e linguagens apropriadas para a compreensão do homem contemporâneo. A Trindade de Deus tem algo importante a dizer para o ser humano de hoje a respeito de si mesmo, pois que feito “à imagem e semelhança de Deus” (Gn 2, 26). Palavras-chave : Trindade. Pai. Filho. Espírito Santo. Amor.The Holy Trinity is the novelty of God presented by Jesus Christ. Without contradicting Jewish monotheism, the reflection for a dogmatic formulation lasted for four centuries. Subsequently, the issue of the trinity was forgotten in the Church for 1,600 years. The importance of this issue is currently being rediscovered not only in the liturgy but also in life and ecclesial reflection. The unity in love on the part of the three distinct persons, Father, Son and Holy Spirit, stimulates spirituality and experience of the Christians today. To do so, one needs the assistance of the humanities that allow the update of the dogma of language without losing its essential content. The reflection of the Neapolitan theologian Bruno Forte is of great value to the current theology because it respects the dogmatic formulation and also uses categories and languages appropriate to an understanding of contemporary man. The Trinity of God has something important to say about the man himself because man was created as God’s image. (Gn 2,26). Keywords : Trinity. Father. Son. Holy Spirit. Love. (shrink)

Neste artigo argumentamos que os temas da ação e da história presentes em alguns contos de Jorge Luis Borges antecipam alguns pontos que apareceram nas discussões pós-estruturalistas - nos campos da história, filosofia, antropologia - das últimas décadas do século XX. No seu labirinto literário-filosófico, especialmente por meio da ideia de destino, Borges explora elementos chave que se tornaram parte da noção de crítica que enfatiza as ideias de contingência e da impossibilidade de controle deliberado dos efeitos da ação humana (...) em seu curso temporal. It is argued in this paper that the themes action and history present in some of Jorge Luis Borges's short stories have anticipated certain aspects of the post-structuralist debates - on history, philosophy, and anthropology - in the last decades of the twentieth century. In his literary and philosophical labyrinth, especially through the idea of destiny, Borges explores key elements that became part of the notion of critique that emphasize the idea of contingency and the impossibility of deliberated control of the effects of human action in its temporal course. (shrink)

El presente artículo es el resultado de un proceso de investigación originado en la Maestría en Publicidad de la UTL, en la línea de Semiótica Publicitaria, dirigida por el profesor Vladimir Sánchez, quien en su seminario, ha venido construyendo un equipo de trabajo con los maestrantes en torno a la aplicabilidad de algunos de los postulados de la pragmática de Charles Sanders Peirce al campo publicitario. Los maestrantes Jairo Sojo y Juan José Arango, adelantaron algunas hipótesis sobre el trabajo (...) del profesor Sánchez, y, gracias a ello, se propuso a la UJTL y a la Universidad Santo Tomás, un proyecto interinstitucional de investigación titulado “Semiótica, planeación y estrategia publicitaria y de diseño. Proyecciones del Pragmatismo a la comunicación contemporánea”. En el marco de la investigación anteriormente mencionada, surge el artículo que aquí se presenta, como un primer planteamiento de las hipótesis de investigación que dan origen a dicho proceso y que pueden esbozarse en tres grandes aspectos. El primero, unas consideraciones generales sobre el pragmatismo desde una perspectiva publicitaria con énfais en la regla de cualificación planteada por Peirce en 1903. El segundo, la propuesta de un modelo de análisis de piezas publicitarias desde la operacionilización de la regla de cualificación. El tercero una modelación para la planeación de estrategias publicitarias a través de la regla de cualificación aplicada al cruce de los interpretantes ontológicos y los interpretantes modales. (shrink)

Pick-and-roll is the most widespread cooperative action among high-level basketball teams and the most applied strategy by coaches to gain an advantage over the rival team. During pick-and-roll, opposing teams perform antagonistic actions based on goals that are expressed in offensive and defensive tactics. The aim of this study is to examine the approaches of high-level coaches on the offensive and defensive dynamics emerging in matches of a basketball elite team during an entire season of the Spanish Asociación de Clubes (...) de Baloncesto league. To this end, we used a mixed-methods approach based on systematic observation of verbatim transcripts of interviews conducted with six high-level coaches about the pick-and-roll dynamics that emerged in matches of the Unicaja Málaga team during an entire season of the ACB league. The observational design was nomothetic, punctual, and multidimensional. The choice of this methodology is justified since we developed an ad hoc indirect observation tool to evaluate the coaches’ perspective on this dynamic. Once the intra-observer reliability of the instrument was confirmed, we performed a polar coordinate analysis to identify the significant relationships between the coaches’ evaluations and the offensive and defensive pick-and-roll elements that supported such verbal behaviors. The results highlight the presence of various offensive and defensive aspects of pick-and-roll emerging in the Unicaja team that were significantly associated with positive and negative evaluations of the coaches. The interview confirms that coach 1 and his staff were less confident in options that pick-and-roll offer, which is also reflected in the record of screens made and simulated, than coach 3. This study shows that the application of mixed methods, by analysis of the polar coordinate of the coding carried out on responses of a systematized interview, has proven to be an effective strategy in obtaining relevant information on the expert knowledge of the elite coaches on the influence of pick-and-roll on tactical actions in basketball. (shrink)

La proporción áurea es señalada por la tradición como un canon de belleza. Este artículo explica el concepto de proporción áurea, empleando como ejemplo la fachada de la capilla de Schönstatt. A continuación se pregunta si hay una base neurológica de la predilección por esta proporción y propone un experimento de magnetoencefalografía para dilucidarlo. Si respeta determinadas condiciones, este experimento puede proporcionar claves más relevantes para este asunto que la medida estética de Birkhoff. Incluso podría cuestionar la opinión (...) de Kant de que el juicio estético es completamente desinteresado. (shrink)

Las profundas transformaciones que han venido ocurriendo en Latinoamérica como consecuencia de los procesos de globalización, han propiciado una serie de transformaciones sociales, institucionales y económicas, tales como las reformas en los Estados, apertura a los mercados financieros, incremento de la tercerización productiva, entre otras, que tienen como consecuencia la segregación y marginalización social progresiva, que no permite a ciertos sectores sociales incorporarse a las dinámicas ..

In the mid-14th century, Henry of Herford wrote the Catena aurea entium, a work of remarkable length and composed of ten books – in turn divided into ansae extending over some 5000 questions. The present study aims to analyse some aspects that the recent critical edition of Book VI of the Catena has brought to light: firstly, the dependence on Albert the Great’s De mineralibus and the compilative method used by Henry in the reworking of his sources; secondly, the main (...) philosophical, medical and encyclopedic sources that structure the treatise on minerals (in which metals are also included); and lastly, the author’s personal contribution, especially highlighting the use of vernacular terms and the recounting of personal experiences, which became useful means in explaining certain natural phenomena such as the formation of fossils or the production of images and seals. (shrink)

Este artigo propõe discutir as formas de representação da identidade dos brasileiros que viveram na cidade de Lagos, em 1888. A ideia é analisar as comemorações que saudaram a notícia da abolição da escravidão no Brasil. Estas festas foram realizadas por brasileiros estabelecidos em território lagosiano, duraram vários dias e ganharam as páginas de jornais como o Lagos Observer e a Government Gazette. Nestes periódicos é possível perceber que alguns dos signos de pertencimento à comunidade foram constituídos por indivíduos de (...) fora do grupo. Estes signos de pertencimento construídos sobre os brasileiros se diferenciavam daqueles formulados pelos próprios brasileiros estabelecidos na cidade. A distinção entre as duas elaborações discursivas registradas pela imprensa lagosiana serve de suporte para pensar as variações dos sentidos de ser brasileiro em Lagos no final do século XIX. Palavras-chave: ideologia da escravidão, Catolicismo africano, inquisição, Igreja Católica, Cabo Verde. (shrink)

Thomas von Aquin behandelt in der Catena aurea jeweils ein Einzelevangelium und kommentiert es durch Autoritätenzitate. Da diese Exzerpte zahlreiche Informationen aus dem Viererkanon zum Inhalt haben, nimmt Thomas stets alle vier Evangelien in den Blick. Sie werden als Ergänzungen und Erklärungen einer Bibelstelle genutzt; insbesondere werden evangelienharmonistische Reflexionen über fehlende und unterschiedliche Aussagen der Evangelisten vorgenommen. Thomas stellt sich in die Reihe der Persönlichkeiten, die bereits dem Vorwurf, die Evangelien enthielten Widersprüche, mit dem Nachweis der Widerspruchslosigkeit zu begegnen suchten. (...) Veranschaulicht wird das harmonistische Bemühen auf der Grundlage der ostmitteldeutschen Übersetzung der Catena aurea super Marcum.Thomas Aquinas deals in Catena aurea steadily one gospel after another. He comments them by quotations of authorities, since those excerpts give numerous information's about the four gospels. Thomas takes permanently all four gospels into consideration and uses them a complement and explanation if each biblical text. He especially reflects missing and distinctive statements. His procedure agrees with those scalars, who tried before to refute the opinion that the gospel texts show contradictions. This harmonistic effort is illustrated in the East Middle German Translation of Catena aurea super Marcum. (shrink)

In this article theaurea dictaof Epicurus (DRN3.12) are placed in conversation with larger discourses related to apian, floral, and honey imagery. Within these literary contexts, bees and honey are often associated with morally suspect appetites, effeminacy, and potentially dangerous erotic entanglements. Lucretius, I argue, seems to allude to these risky literary valences and manipulates them for his own poetic and rhetorical ends. Honey, we discover, is much more than a sugary substance.

The growing body of literature on the idea of the Anthropocene has opened up serious questions that go to the heart of the social and human sciences. There has been as yet no satisfactory theoretical framework for the analysis of the Anthropocene debate in the social and human sciences. The notion of the Anthropocene is not only a condition in which humans have become geologic agents, thus signalling a temporal shift in Earth history: it can be seen as a new (...) object of knowledge and an order of governance. A promising direction for theorizing in the social and human science is to approach the notion of the Anthropocene as exemplified in new knowledge practices that have implications for governance. It invokes new conceptions of time, agency, knowledge and governance. The Anthropocene has become a way in which the human world is re-imagined culturally and politically in terms of its relation with the Earth. It entails a cultural model, that is an interpretative category by which contemporary societies make sense of the world as embedded in the Earth, and articulate a new kind of historical self-understanding, by which an alternative order of governance is projected. This points in the direction of cosmopolitics – and thus of a ‘Cosmopolocene’ – rather than a geologization of the social or in the post-humanist philosophy, the end of the human condition as one marked by agency. (shrink)

Graphical AbstractThe membrane lipids of archaea and bacteria are typically very different, a dichotomy known as the “lipid divide”. However, it is now known that archaeal and bacterial lipids can form stable membranes, both in the lab and in nature. So why don't they? If not lipids themselves, the lipid divide may be driven by adverse interactions of membrane proteins with foreign lipids. More details can be found in the Hypothesis article 1800251 by Victor Sojo, Why the Lipid Divide? (...) Membrane Proteins as Drivers of the Split between the Lipids of the Three Domains of Life, DOI: 10.1002/bies.201800251. (shrink)

Recent results from engineered and natural samples show that the starkly different lipids of archaea and bacteria can form stable hybrid membranes. But if the two types can mix, why don't they? That is, why do most bacteria and all eukaryotes have only typically bacterial lipids, and archaea archaeal lipids? It is suggested here that the reason may lie on the other main component of cellular membranes: membrane proteins, and their close adaptation to the lipids. Archaeal lipids in modern bacteria (...) could suggest that the last universal common ancestor (LUCA) had both lipid types. However, this would imply a rather elaborate evolutionary scenario, while negating simpler alternatives. In light of widespread horizontal gene transfer across the prokaryotic domains, hybrid membranes reveal that the lipid divide did not just occur once at the divergence of archaea and bacteria from LUCA. Instead, it continues to occur actively to this day. Also see the video abstract here https://youtu.be/TdKjxoDAtsg. (shrink)

A great amount of literature documents young children’s innate interest in discovering their surroundings and gradually developing more complex activities and thoughts. It has been demonstrated that when environments support young children’s innate interest and progressive autonomy, they help children acquire a self-determined behavior. However, little is known about the application of this evidence in the daily practice of early childhood educational settings. This study examines Emmi Pikler Nursery School, a center that implements an autonomy-supportive educational approach. We conducted a (...) systematic observation of two experienced Pikler educators while they accompanied young children’s free play. Our objective was to assess: if educators’ instrumental action follows a systematic behavioral sequence; if each instrumental action is supported by specific relational behaviors; and if educators display differentiated intervention levels with regards to children’s free play through the adaptation of the relational dimension. We conducted lag sequential analysis in order to find behavioral patterns and concurrences between the observed behaviors. Our findings indicate that educators perform systematic action sequences and that each of the instrumental actions of those sequences has a specific relational value. We conclude that educators display three differentiated intervention levels depending on the child and the circumstances of the moment, providing an appropriate autonomy support and reinforcing children’s self-determination. (shrink)